There are many uses of CD molecules, not only participating in the recognition of antigens, capturing antigens, promoting the interaction between immune cells and antigens or immune molecules, but also mediating the adhesion between immune cells, immune cells and matrix, in the immune response. And play an important role in both activation and effector phases.
What is cluster of differentiation (CD)?
Cluster of differentiation (also known as differentiation group or simply Cluster of differentiation, CD) refers to the cell surface molecules used to identify those used for immune antigen recognition. Physiologically, CD molecules are usually used as important receptors or ligands of cells; in addition, some CDs can be used in the signaling cascade of cells (cascade reaction), thereby changing the behavior of cells; some CD proteins are not related to cell communication, but has other function, such as a cell adhesion.
More than 400 molecules have been characterized and given official names as a result of the information produced by the 10 human Leuckocyet difference antigen workshop over the past 30 years.
Leuckocyet population subset and differentiation stage can all be identified and isolated using cd molecules, which are frequently used as cell markers. mAbs directed against those molecules have proven to be crucial in biotechnology.
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